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Schizophrenia - causes, symptoms, diagnosis, treatment & pathology

 Schizophrenia



Definition - A disorder that affects a person's ability to think, feel and behave clearly.

The exact cause of schizophrenia isn't known, but a combination of genetics, environment and altered brain chemistry and structure may play a role

Symptoms



5Main Symptoms

Delusions. These are false beliefs that are not based in reality. ... 

Hallucinations. These usually involve seeing or hearing things that don't exist. ... 

Disorganized thinking (speech). Disorganized thinking is inferred from disorganized speech. ... 

Extremely disorganized or abnormal motor behavior. ... 

Negative symptoms.



CAUSES 

Research suggests schizophrenia may be caused by a change in the level of 2 neurotransmitters: dopamine and serotonin.

5Imp causes

Genetics. One of the most significant risk factors for schizophrenia may be genes. ... 

Structural changes in the brain. ... 

Chemical changes in the brain. ... 

Pregnancy or birth complications. ... 

Childhood trauma. ... 

Previous drug use.



Medications: The primary medications used to treat schizophrenia are called antipsychotics. These drugs don’t cure schizophrenia but help relieve the most troubling symptoms, including delusions, hallucinations, and thinking problems.

Older (commonly referred to as "first-generation") antipsychotic medications used include:

Chlorpromazine (Thorazine)

Fluphenazine (Prolixin)

Haloperidol (Haldol)

Loxapine HCL (Loxapine)

Perphenazine (Trilafon)

Thiothixene (Navane)

Trifluoperazine (Stelazine)

Newer ("atypical" or second-generation) drugs used to treat schizophrenia include:

Aripiprazole (Abilify)

Aripiprazole Lauroxil (Aristada)

Asenapine (Saphris)

Brexpiprazole (Rexulti)

Cariprazine (Vraylar)

Clozapine (Clozaril)

Iloperidone (Fanapt)

Lumateperone (Caplyta)

Lurasidone (Latuda)

Olanzapine (Zyprexa)

Olanzapine/samidorphan (Lybalvi)

Paliperidone (Invega Sustenna)

Paliperidone (Invega Trinza)

Quetiapine (Seroquel)

Risperidone (Risperdal)

Ziprasidone (Geodon)

🔸Coordinated speciality care(csc) 

🔸Psychosocial therapy

-Rehabilitation 

-cognitive Remediation 

-Individual psychotherapy 

-Family therapy 

-Group therapy /support group


🔸Hospitalizations 

🔸Electroconvulsive therapy (ECT) 




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